(Sethibelo sa mali bokong, BBB)
Tšitiso ea mali le boko ke e 'ngoe ea mekhoa ea bohlokoa ea ho itšireletsa ho batho.E entsoe ka lisele tsa boko tsa capillary endothelial, lisele tsa glial, le plexus ea choroid, e lumellang mefuta e itseng feela ea limolek'hule tse tsoang maling ho kena methapong ea boko le lisele tse ling tse potolohileng, 'me e ka thibela lintho tse sa tšoaneng tse kotsi ho kena liseleng tsa boko.Boko, joalo ka karolo ea lekunutu le ea bohlokoa ea 'mele oa motho, bo laola mesebetsi e mengata ea bohlokoa.Tšitiso ea mali le boko e ka thibela lintho tse kotsi maling le ho sireletsa polokeho ea lisele tsa boko.
Lefu la Alzheimer, AD
Lefu la Alzheimer (AD) ke lefu le ntseng le tsoela pele le senyang methapo ea kutlo le ho qala ka bolotsana.Ts'ebetsong ea bongaka, 'dementia' e akaretsang e tšoauoa ka ho senyeha ha mohopolo, aphasia, aphasia, ho lahleheloa ke tlhokomelo, ho senyeha ha litsebo tsa pono le sebaka, ho se sebetse ha tsamaiso, le botho le liphetoho tsa boitšoaro.Etiology e ntse e sa tsejoe.'dementia' ea pele ho nako e bolela batho ba bang le matšoao pele ba le lilemo li 65;Batho ba nang le 'dementia' ka mor'a lilemo tse 65 ba bitsoa senile dementia.Ho hlaha ha lefu la Alzheimer (AD) hangata ho amahanngoa le β- Amyloid protein (A β） Accumulation le Tau protein entanglement li hokahane, 'me butle-butle liphuputso li thathamisa neuroinflammation e le e' ngoe ea mabaka a tlatsetsang ho hlaha ha AD.
Khopolo: Lefu la Alzheimer ke eng?Sheba tsebo ena.Batho ba Letsatsi le Letsatsi Inthaneteng.2023-09-20
Hlokomela hore ho na le mofuta oa libaktheria tse ka phunyeletsang mokoallo oa mali le boko
Haufinyane tjena, bafuputsi ba Baylor College of Medicine ea United States ba phatlalalitse pampiri ea lipatlisiso e nang le sehlooho se reng: Toll like receptor 4 le CD11b e hlahisitsoeng ka microglia coordinate erasure ea Candida albicans cerebral mycosis koranteng ea Cell Reports.
Re fumane fungus e bitsoang Candida albicans e ka kenang bokong ka phallo ea mali.Joalokaha polelo e tsebahalang e bolela, “Ho raha leoto la motho ea holofetseng ho ka baka lefu la Alzheimer joaloka liphetoho.”Thutong ena, re boetse re senola mekhoa ea limolek'hule eo Candida albicans e phunyeletsang mokoallo oa mali-bokong ebe e kena bokong, e lebisang ho lefu la Alzheimer joaloka liphetoho.
Candida albicans e kena joang bokong?"Re fumane hore Candida albicans e hlahisa enzyme e bitsoang secreted aspartate protease (Saps), e senyang mokoallo oa mali-boko, e lumellang li-fungus ho kena bokong le ho baka tšenyo," ho boletse Dr. Yifan Wu, rasaense oa postdoctoral oa bana ea sebetsang Corry. Laboratori.
Candida albicans
Candida albicans (lebitso la mahlale: Candida albicans) ke tomoso e ka bakang mafu a nkang monyetla.E fumanoa hangata sechabeng sa baktheria sa tšilo ea lijo ea motho le lipampitšana tsa urogenital.Hoo e ka bang 40% ho isa ho 60% ea batho ba baholo ba phetseng hantle ba na le Candida albicans lipampitšaneng tsa bona tsa molomo le tsa tšilo ea lijo.Li-albicans tsa Candida hangata li phela hammoho le 'mele oa motho, empa li ka hola haholo nakong ea ho haella ha' mele oa 'mele le ho baka candidiasis.Ke baktheria ea pathogenic e atileng haholo ho mofuta oa Candida
Ho ea ka phuputso e entsoeng ho Cell Reports, li-fungus tseo hangata re sa li ele hloko haholo e ka ’na ea e-ba e ’ngoe ea lisosa tsa lefu la Alzheimer.Bafuputsi ba Baylor School of Medicine le mekhatlo e kopanetsoeng ba sibolotse ka mehlala ea liphoofolo hore na Candida albicans e kena bokong joang le hore na e kenya tšebetsong mekhoa e 'meli e ikemetseng ea lisele tsa boko tse khothalletsang ho tlosoa ha eona (e leng bohlokoa ho utloisisa tsoelo-pele ea lefu la Alzheimer's). β Amyloid protein (A β) Peptides (metsoana ea chefo ea protheine ea amyloid) e nkoa e le motheo oa nts'etsopele ea lefu la Alzheimer's.
Dr. David Corry o boletse.David Corry ke Molulasetulo oa Pathology ho Fulbright Foundation le moprofesa oa mafu, immunology, le meriana Univesithing ea Baylor.Hape ke setho sa Baylor L. Duncan Comprehensive Cancer Center.Ka 2019, re fumane hore Candida albicans ehlile e kene bokong mme ea hlahisa liphetoho tse ts'oanang haholo le lefu la Alzheimer's.Ho ruruha ho bakoang ke Candida albicans hangata ho tsamaea le
A β Lebaka la tlhahiso ea li-amyloid tse kang li-peptide ke hore Sap e ka hydrolyze amyloid precursor proteins (APPs).
Leha ho le joalo, li-peptide tsena li boetse li hohela tlhokomelo ea lisele tsa 'mele tsa boko - microglia, e leng bohlokoa bakeng sa ho hlakoloa ha Candida albicans ke boko ka boeona.Ntle le moo, chefo ea Candidalysin e hlahisoang ke Candida albicans e kenya tšebetsong microglia ka tsela e 'ngoe.Haeba tsela ena e senyeha, li-fungus bokong li ke ke tsa felisoa.
Bafuputsi ba bontša hore mosebetsi ona o ka fetoha papali ea bohlokoa bakeng sa ho utloisisa ho hlaha ha lefu la Alzheimer.Liphuputso tse fetileng li bonts'itse hore li-protease bokong li na le seabo ho senyeheng ha lits'ebetso 'me li kenya letsoho ho A β Pokello ea ho thehile motheo.Mme jwale ho ka netefatswa hore protease ena e sa tlwaelehang e tswang ho fungus le yona e ka baka tlhahiso ya A β Peptide.
Bafuputsi ba supa hore tlhahlobo e 'ngoe ea karolo ea Candida albicans ho nts'etsopele ea lefu la Alzheimer e ea hlokahala nakong e tlang, e ka lebisang maqheka a macha a kalafo bakeng sa AD.
Lisebelisoa tsa litšupiso:
[1] Yifan Wu et al, Toll like receiver 4 le CD11b e hlalositsoeng ka microglia coordinate erasure ea Candida albicans cerebral mycosis, Cell Reports (2023) DOI: 10.1016/j.celrep.2023.113240
[2] Lihlahisoa tsa ts'oaetso ea boko bo sebetsang bo bakoang ke lefu la Alzheimer's joalo ka liphetoho, ho re thuto e ncha E tlisitsoe ka la 17 Mphalane, 2023 ho tsoa ho https://medicalxpress.com/news/2023-10-brain-fungal-infection-alzheimer-disease-like.html
Nako ea poso: Dec-22-2023